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Mid-Wilshire is a district in the City of Los Angeles, California. It is part of the Wilshire region.

It mostly encompasses the area bounded by La Cienega Boulevard on the west, Melrose Avenue on the north, Hoover Street on the east, and the Santa Monica Freeway on the south, although some neighborhoods in this perimerter are part of Mid-City West. It derives its name from Wilshire Boulevard, the primary east-west thoroughfare through the area. The service area of the Wilshire Division of the Los Angeles Police Department is congruent to the portions of Mid-Wilshire within the City of Los Angeles. A very popular nickname among locals for this district is Midtown.